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Om du exempelvis stukar fotleden skickas en smärtsignal upp genom nervsystemet till hjärnan by means of opioidreceptorerna. Mellan 2000 och 2010 ökade OxyContin-konsumtionen i United states ytterligare. För en del patienter innebar den ökade konsumtionen att de utvecklade tolerans mot OxyContin och därför sökte sig until mer potenta droger